Given complexities currently underpinning multipolar realities of the international system, it seems that a pluralist internationalism is becoming a strategic consideration for a post-Western world order. This warrants new agendas for cooperation. Based on the latter this analysis examines to what extent the BRICS can articulate such a new agenda based on a South African-informed perspective. This involves exploring the basis of a BRICS-African agenda competing with the geo-political interests of sub-groupings such as the SCO, RIC, and the EAEU.